John tracks down Santino and finally agrees to do one job for him. Santino wants John to kill his sister Gianna (Claudia Gerini), who is set to ascend to the High Table, a group of powerful assassins.

John argues that this is an impossible target to which Santino replies that this is exactly why he wanted John for the task. Seeing no way out of it, John travels to Rome to complete the task. He stays at the Rome Continental, owned by Julius (Franco Nero). John meets with suppliers to prepare - a tailor to buy custom, bullet-resistant lined suits, a historian to obtain maps of the catacombs, and an armorer to procure weapons. John attends a party that is Gianna's 'coronation' and welcome to the High Table. She is accompanied by her loyal bodyguard Cassian (Common). John sneaks into Gianna's room and confronts her alone. She warns him of the events that will unfold once she is dead. She chooses to die on her own terms by slitting her wrists.

In honor of their past friendship, John holds her hand until she passes out. To grant his friend an honest chance at Paradise without the weight of suicide which her Catholic religion prohibits, and to claim the marker, John shoots her in the head. Upon learning that John is working, Cassian draws his weapon, as does John, and each shoots the other, though they are uninjured due to their bullet-resistant clothing.

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